Please use this identifier to cite or link to this item: http://rdcb.cbg.ipn.mx/handle/20.500.12273/82
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dc.rights.licensehttp://creativecommons.org/licenses/by-nc/4.0es_MX
dc.creatorEDGAR EDUARDO LARA RAMIREZes_MX
dc.date.accessioned2018-07-06T15:05:18Z-
dc.date.available2018-07-06T15:05:18Z-
dc.date.issued2014-07-17-
dc.identifier.urihttp://rdcb.cbg.ipn.mx/handle/20.500.12273/82-
dc.description.abstractThe increasing number of dengue virus (DENV) genome sequences available allows identifying the contributing factors to DENV evolution. In the present study, the codon usage in serotypes 1–4 (DENV1–4) has been explored for 3047 sequenced genomes using different statistics methods.The correlation analysis of total GC content (GC) with GC content at the three nucleotide positions of codons (GC1, GC2, and GC3) as well as the effective number of codons (ENC, ENCp) versus GC3 plots revealed mutational bias and purifying selection pressures as the major forces influencing the codon usage, but with distinct pressure on specific nucleotide position in the codon. The correspondence analysis (CA) and clustering analysis on relative synonymous codon usage (RSCU) within each serotype showed similar clustering patterns to the phylogenetic analysis of nucleotide sequences for DENV1–4.These clustering patterns are strongly related to the virus geographic origin. The phylogenetic dependence analysis also suggests that stabilizing selection acts on the codon usage bias. Our analysis of a large scale reveals new feature on DENV genomic evolution.es_MX
dc.language.isoenges_MX
dc.publisherHindawi-
dc.rightsinfo:eu-repo/semantics/openAccesses_MX
dc.sourceBioMed Research International. Vol. 2014. 2014-
dc.titleLarge-scale genomic analysis of codon usage in dengue virus and evaluation of its phylogenetic dependencees_MX
dc.typeinfo:eu-repo/semantics/articlees_MX
dc.creator.idinfo:eu-repo/dai/mx/cvu/230904es_MX
dc.subject.ctiinfo:eu-repo/classification/cti/3es_MX
dc.subject.keywordsInfluenza A viruses_MX
dc.subject.keywordsH1N1es_MX
dc.subject.keywordsPandemices_MX
dc.subject.keywordsEpitopeses_MX
dc.subject.keywordsGenome comparisones_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
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